a Record control number WOS:000338504300006

a ISSN 1880-6546

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QT104

b Item number .P76 2014

a Personal name Izgut-Uysal, V. Nimet.

h Medium Electronic Document

a Title The protective effect of apelin against water-immersion and restraint stress-induced gastric damage

c Statement of responsibility, etc V. Nimet Izgut-Uysal, Burcu Gemici, Ilknur Birsen, Nuray Acar, Ismail Ustunel.

a Place of publication, distribution, etc Springer Japan KK,

c Date of publication, distribution, etc 2014.

b Name of publisher, distributor, etc Tokyo

a Summary, etc The aim of the present study was to investigate the gastroprotective effect of apelin on water-immersion and restraint stress (WIRS)-induced gastric lesions. Male Wistar rats were divided into four groups: control, WIRS, F13A + WIRS and F13A. APJ receptor antagonist F13A was administered to rats to determine the influence of apelin on stress-induced gastric injury. WIRS administered for 6 h resulted in the development of gastric mucosal lesions accompanied by a significant increase in plasma corticosterone. WIRS increased the concentration of 4-hydroxynonenol (4-HNE) + malondialdehyde (MDA) and the expression of apelin and hypoxia inducible factor-1 alpha (HIF-1 alpha) in gastric mucosa. In addition, WIRS reduced the mucosal blood flow and gastric prostaglandin E-2 (PGE(2)) concentration. Plasma corticosterone, which was increased due to stress, was significantly decreased in the F13A + WIRS group. Gastric lesions and the 4-HNE + MDA concentration were also higher in the F13A + WIRS compared to the WIRS group. We conclude that apelin has a gastroprotective effect against stress-induced lesions possibly by reducing lipid peroxidation in gastric mucosa.

a Topical term or geographic name as entry element Physiology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Gastric mucosal injury

a Topical term or geographic name as entry element Apelin

a Topical term or geographic name as entry element APJ antagonist

a Topical term or geographic name as entry element Receptor Messenger-RNA

g Relationship information JUL 2014, Vol 64 Issue 4, p279-289

x International Standard Serial Number 1880-6546

t Title Journal Of Physiological Sciences

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s12576-014-0317-8